DOMI UP ORAL SPRAY

Domi UP Oral Spray is a medicine given to children to help treat nausea and vomiting. It is mainly given to treat nausea and vomiting associated with surgery, chemotherapy, radiotherapy, and stomach/intestinal infection. It also helps treat vomiting that is caused as a side effect of medicines like painkillers. Domi UP Oral Spray may be given before or after meals. To control vomiting caused due to chemotherapy, give this medicine to your child 30 minutes before the procedure. Give it 1 to 2 hours before a radiotherapy session and 1 hour before surgery to prevent your child from vomiting post these procedures. If your child expels out the medicine within 30 minutes of the intake, help your child calm down and repeat the dose. Do not double the dose if it is already time for the next dose.Domi UP Oral Spray may cause some temporary side effects such as headache, constipation, diarrhea, and fatigue. These side effects usually subside once your child’s body adapts to the medicine. In case these side effects persist or become bothersome, do reach out to the doctor on a priority basis.Let the doctor know about all the medicines your child is taking, including painkillers, antibiotics, or medicines taken to treat depression. Also, inform the doctor if your child has a history of liver problems, kidney malfunction, blockage in the gastrointestinal tract, heart problems, or allergies to any medicine, its ingredients, or a food product. This information is very important for dose alterations and for planning your child’s overall treatment.

Commonly bought for:

SALT CATEGORY: GENERAL

4/7 pharmacies priced

7 pharmacies checked

4 prices found

ApolloIn stock₹42.00Only price— open Apollo in a new tab
MedPlusOut of stock₹74.71
PharmEasyOut of stock₹91.05
PlatinumRxOut of stock₹133.90

No price found yet at 1mg (Tata), Netmeds, Truemeds. They may still stock it.

Prices come from pharmacy websites and can change. “Checked” is when we last read that pharmacy's page, not when the price last changed. Confirm on the pharmacy's own page before you order.

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medicationDosage & Packaging Details

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Dosage Form

Oral Solution

Manufacturer

Domi UP

Administration

Oral Route

Prescription

prescription

action class: Serotonin 5-HT3 Receptor Antagonistshabit forming: Notherapeutic class: GASTRO INTESTINAL

medical_informationMedicine & Clinical Information

check_circleUses & Indications

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Vomiting
Nausea

lightbulbExpert Advice & Quick Tips

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arrow_rightDomi UP Oral Spray effectively controls nausea and bouts of vomiting reflex in children undergoing chemotherapy or radiotherapy sessions.
arrow_rightIt is fast-acting and starts working within 30 minutes.
arrow_rightPractice self-care measures:Give plenty of fluids to your child to avoid dehydrationAvoid giving fried and spicy food or heavy meals to your child.Ensure that your child eats slowly and in small proportions.
arrow_rightGive plenty of fluids to your child to avoid dehydration
arrow_rightAvoid giving fried and spicy food or heavy meals to your child.
arrow_rightEnsure that your child eats slowly and in small proportions.

scienceMechanism of Action (How it works)

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During radiotherapy, chemotherapy, abdominal infection, or any major surgeries, the dead cells in the body start releasing a chemical called serotonin directly into the blood. Later, this stimulates special centers in the body that are responsible for inducing vomiting in your child. Giving Domi UP Oral Spray just before the procedure helps block the effect of this chemical on vomiting centers of the brain and prevents vomiting.

infoDirections for Use (How to Use)

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Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Domi UP Oral Spray may be taken with or without food.

historyMissed Dose Instructions

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Do not panic. Give the missed dose as soon as you remember. However, you must skip the missed dose if it’s almost time for the next dose. Do not give a double dose and follow the prescribed dosing schedule.

warningSide Effects

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Fatigue
Headache
Constipation
Diarrhea

helpFrequently Asked Questions

What if my child takes too much Domi UP Oral Spray?

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Domi UP Oral Spray is unlikely to cause harm if you give an extra dose by mistake. However, you must still speak to your child’s doctor immediately. Sometimes, excessive intake of Domi UP Oral Spray can cause some serious side effects like excess sleepiness, agitation, rapid heartbeat, hypertension, flushing, dilated pupils, sweating, involuntary muscle jerk, uncontrolled eye movements, overactive reflexes, and seizures. These symptoms are collectively known as serotonin syndrome. If any of these appear, consult the doctor without any delay.

How should Domi UP Oral Spray be stored?

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Domi UP Oral Spray should be stored at room temperature, in a dry place, away from direct heat and light. Also, keep all the medicines out of the reach and sight of children to avoid any accidental intake.

What all medicines should my child avoid while taking Domi UP Oral Spray?

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Usually, it is advised not to give Domi UP Oral Spray along with antidepressant medicines, apomorphine, anti-migraine medicines, painkillers, heart medicines, and antibiotics like linezolid. But, it is ideal to speak to your child’s doctor before coming to any conclusion. So, narrate your child’s complete medical history to your child’s doctor and follow their advice strictly.

In what conditions do I need to call my child’s doctor right away?

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Call your child’s doctor immediately if your child develops symptoms of serotonin syndrome like irregular heartbeat, green-colored vomiting, inability to pass wind, pale skin and eyes, dark-colored urine, restlessness, and insomnia.

My child is having a migraine and is on medication. Can I give Domi UP Oral Spray along with it?

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Avoid combining Domi UP Oral Spray with such medicines because concomitant use of Domi UP Oral Spray with medicines meant to treat depression or migraine results in serotonin syndrome. Consult your child’s doctor before giving any medicine to your child.

Editorial & Medical Review

The information on this page has been compiled and reviewed by healthcare professionals and data editors to ensure accuracy. It is for informational and price-comparison purposes only and should not replace professional medical advice.

Written By

MediSaathi Editorial Team

Last Updated

June 21, 2026

Regularly reviewed

Data Sources & Citations

Central Drugs Standard Control Organisation (CDSCO) — Government of IndiaView Source
National Pharmaceutical Pricing Authority (NPPA) — Government of IndiaView Source
Jan Aushadhi Scheme — Pradhan Mantri Bhartiya Janaushadhi Pariyojana — Government of IndiaView Source

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Price Summary for DOMI UP ORAL SPRAY

DOMI UP ORAL SPRAY

7 pharmacies checked

vaccinesMost Viewed Alternatives

Doctor Consultation Required

medical_informationMedicine & Clinical Information

helpFrequently Asked Questions

Editorial & Medical Review

Data Sources & Citations