DEPAKOTE XR 500 TABLET

Depakote XR 500 Tablet is a medication used to treat epilepsy, seizures, bipolar disorder, mania, trigeminal neuralgia, and migraines. It works by stabilizing brain activity. Always use it under medical supervision for safe and effective treatment. Depakote XR 500 Tablet may be used alone or in combination with other medicines. Your doctor will determine the appropriate dose and frequency to effectively control your symptoms. You can take this medicine with or without food, but for the best results, take it at the same time each day. It usually takes a couple of weeks to work. It is important to take this medicine regularly and for as long as you are advised, even if you feel well. Missing doses may trigger seizures, and if you stop, your condition may get worse. It should never be stopped suddenly.The most common side effects of Depakote XR 500 Tablet include headache, constipation, nausea, vomiting, dizziness, weight gain, rash, back pain, and abdominal pain. Most of these are not serious. Continue taking the medicine, but

Commonly bought for:

SALT CATEGORY: GENERAL

4/7 pharmacies priced

7 pharmacies checked

3 prices found

ApolloIn stock₹404.00Only price— open Apollo in a new tab
PlatinumRxOut of stock₹353.72
NetmedsOut of stock₹359.92

No price found yet at PharmEasy, 1mg (Tata), Truemeds, MedPlus. They may still stock it.

Prices come from pharmacy websites and can change. “Checked” is when we last read that pharmacy's page, not when the price last changed. Confirm on the pharmacy's own page before you order.

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medical_informationMedicine & Clinical Information

check_circleUses & Indications

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Mania
Migraine
Treatment of Bipolar disorder
Trigeminal neuralgia
Treatment of Epilepsy/Seizures
Seizures
Epilepsy

lightbulbExpert Advice & Quick Tips

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arrow_rightTake your medication regularly as directed by your doctor, as missing doses can trigger seizures.
arrow_rightTake it at the same time every day to maintain consistent levels in your body.
arrow_rightIt can be taken with or without food; however, consider taking it with food to avoid an upset stomach.
arrow_rightDo not change the brand of your medicine, and make sure that you have a sufficient amount of medicine present with you.
arrow_rightIt may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
arrow_rightMonitor your weight during treatment with this medicine, as it can cause weight gain.
arrow_rightYour doctor may get regular blood tests done to monitor how the medication is affecting your body. Inform your doctor if you notice yellowing of the eyes or skin, dark urine, or stomach pain.
arrow_rightAvoid consuming alcohol when taking Depakote XR 500 Tablet, as it may cause excessive sleepiness or drowsiness.
arrow_rightInform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
arrow_rightDo not take Depakote XR 500 Tablet if you are pregnant or planning to conceive or breastfeed.

scienceMechanism of Action (How it works)

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Depakote XR 500 Tablet works by calming overactive nerve signals in the brain. It increases certain chemicals that help control brain activity, prevent seizures, stabilize mood in bipolar disorder, and reduce migraine frequency. Balancing brain signals helps manage symptoms effectively and improves overall well-being.

infoDirections for Use (How to Use)

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Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depakote XR 500 Tablet may be taken with or without food.

historyMissed Dose Instructions

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If you miss a dose of Depakote XR 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

warningSide Effects

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Dizziness
Nausea
Vomiting
Headache
Fatigue
Tremors
Diarrhea
Weight
Hairloss
Rash

medicationDosage & Packaging Details

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Dosage Form

Tablet ER

Manufacturer

Depakote

Administration

Oral Route

Prescription

prescription

action class: Sodium Channel Modulators- Antiepileptic drugs (AEDs)habit forming: Notherapeutic class: NEURO CNS

helpFrequently Asked Questions

What happens if I stop taking Depakote XR 500 Tablet?

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You should not stop taking Depakote XR 500 Tablet without consulting your doctor. The dose of Depakote XR 500 Tablet should be reduced gradually and eventually can be stopped under the supervision of a doctor or specialist. Suddenly stopping the medication may trigger seizures or lead to the recurrence of symptoms.

Is Depakote XR 500 Tablet a mood stabilizer?

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Yes, Depakote XR 500 Tablet can sometimes be used as a mood stabilizer. It is given in patients who experience rapid changes in their mood. It works by calming the hyperactivity of the brain during mood changes.

Can Depakote XR 500 Tablet cause weight gain?

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Yes, Depakote XR 500 Tablet may cause weight gain. The gain in weight could be due to an increase in hunger. Keep a check on your diet and exercise regularly to prevent any weight gain. If you are have concerns related to weight gain, consult your doctor.

Does Depakote XR 500 Tablet make you sleepy?

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Yes, Depakote XR 500 Tablet may make you feel sleepy. Avoid driving or other work that requires mental focus until you know how it affects you.

Does Depakote XR 500 Tablet cause hair loss?

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Yes, Depakote XR 500 Tablet may cause hair loss. However, it is only for a short time and is usually dose-related. Consult your doctor if the hair loss bothers you or persists for a longer duration.

Editorial & Medical Review

The information on this page has been compiled and reviewed by healthcare professionals and data editors to ensure accuracy. It is for informational and price-comparison purposes only and should not replace professional medical advice.

Written By

MediSaathi Editorial Team

Last Updated

July 7, 2026

Regularly reviewed

Data Sources & Citations

Central Drugs Standard Control Organisation (CDSCO) — Government of IndiaView Source
National Pharmaceutical Pricing Authority (NPPA) — Government of IndiaView Source
Jan Aushadhi Scheme — Pradhan Mantri Bhartiya Janaushadhi Pariyojana — Government of IndiaView Source

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Price Summary for DEPAKOTE XR 500 TABLET

DEPAKOTE XR 500 TABLET

7 pharmacies checked

vaccinesMost Viewed Alternatives

Doctor Consultation Required

medical_informationMedicine & Clinical Information

helpFrequently Asked Questions

Editorial & Medical Review

Data Sources & Citations